It is highly recommended that you make a back-up copy of your EndNote library to guard against damage/loss. This also enables you take your EndNote library with you to another location and to email part or all of your library to your colleagues.
Your library in EndNote comprises a .enl file and a .DATA folder which holds various files connected with the library. Both Save a Copy and saving your library as a compressed library includes the .DATA folder.
Use these 2 different methods for different purposes:
Save as a compressed library file to your USB for moving between computers or sharing your library:
To restore your compressed library file:
Save a Copy of your library on a different drive or USB as a back-up at a specific point in time.